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AngioChem announces two new peer-reviewed publications.


Montreal, Canada – AngioChem is pleased to announce the publication of two new scientific articles, as well as a related commentary describing the mechanism and therapeutic potential of the company’s Angiopep drug-delivery technology and its lead product for brain cancer, ANG1005. The articles are:

  • Regina et al. - British J. of Pharmacology .- Antitumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2.- (2008), 1–13,0007–1188/08
  • Demeule et al. -  Journal of Neurochemistry. - Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2 .- (2008).-  10.1111/j.1471-4159.2008.05492.x
  • Mazza et al. - British J. of Pharmacology .- Cancer and blood-brain barrier: ‘Trojan horses’ for courses?.- (2008), 1–3,0007–1188/08

The paper by Demeule et al in the Journal of Neurochemistry describes the latest results on the mechanism of action of the Angiopep brain drug delivery system. The paper by Regina et al in the British Journal of Pharmacology demonstrates the activity of ANG1005, a conjugate of the chemotherapy drug paclitaxel linked to Angiopep, against human tumor cell lines implanted in mice, including increased survival in a brain tumor model. A related commentary by Mazza et al discusses the significance of the Regina paper as a milestone for drug delivery to the brain and a starting point for further investigation.


“We are gratified by the growing scientific and commercial interest in our Angiopep technology since our first publication earlier this year in the Journal of Pharmacology and Experimental Therapeutics,” said Dr. Jean-Paul Castaigne, Chief Executive Officer of AngioChem. “The two new articles and two additional publications expected by the end of the year reinforce our conviction that we can deliver new therapies to the brain for challenging diseases such as brain cancer, Alzheimer’s disease and chronic pain.”

About AngioChem // AngioChem is a Canadian clinical-stage biotechnology company dedicated to creating and developing new drugs to treat brain diseases. We leverage a breakthrough platform technology capable of physiologically transporting molecules across the Blood-Brain Barrier and currently lead this field. Our Angiopep platform technology enables delivery of any drug or drug candidate to the brain. Our approach creates patentable New Chemical Entities (NCE). We are currently validating our platform technology in humans with ANG1005 in two parallel phase 1/2 studies. We are also leveraging our technology, internally and with partners, by creating other NCEs with small molecules, peptides, monoclonal antibodies, siRNA, etc. to treat various brain diseases. A detailed description of AngioChem’s activities is available at